Duloxetine: SNRI antidepressant for depression, anxiety and chronic pain
Duloxetine is an SNRI antidepressant used to treat major depression, generalized anxiety disorder, and chronic pain conditions. How it works, side effects, and what to expect.
What is duloxetine?
Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI). It increases levels of serotonin and norepinephrine in your brain to improve mood, reduce anxiety, and manage pain signals.
What duloxetine treats
Duloxetine is FDA-approved for:
- Major depressive disorder
- Generalized anxiety disorder (GAD)
- Chronic musculoskeletal pain
- Diabetic peripheral neuropathic pain
- Fibromyalgia
- Chronic pain due to osteoarthritis
Doctors may also prescribe it off-label for other pain conditions or anxiety disorders.
How to take duloxetine
Duloxetine comes as a capsule. Standard dosing starts at 30 mg or 60 mg once daily. Your doctor may adjust your dose based on how you respond and any side effects.
Swallow capsules whole. Do not open, crush, or chew them.
Common side effects
- Nausea
- Drowsiness
- Dizziness
- Dry mouth
- Headache
- Fatigue
Side effects often improve within the first few weeks as your body adjusts.
Important considerations
Tell your doctor if you take other medications, especially other antidepressants, pain relievers, or blood thinners. Duloxetine can interact with several drug classes.
Do not stop taking duloxetine suddenly. Stopping abruptly can cause withdrawal symptoms. Your doctor will help you taper your dose gradually when stopping.
If you are pregnant, planning pregnancy, or breastfeeding, discuss duloxetine use with your doctor.
Getting duloxetine
Duloxetine is available by prescription. Telemedicine and telehealth providers can prescribe it after a consultation. Generic duloxetine is usually available and more affordable than brand-name Cymbalta.