Enclomiphene: What It Is and How It Works
Enclomiphene is the active isomer of clomiphene that stimulates testosterone production. Learn how it works, what to expect, and current prescribing status.
Enclomiphene is the active form of clomiphene, a selective estrogen receptor modulator (SERM) that works by blocking estrogen's feedback on the pituitary gland. This allows your body to produce more of its own testosterone.
How It Works
Unlike testosterone replacement therapy, which shuts down your natural testosterone production, enclomiphene stimulates your body to make more testosterone on its own. It does this by reducing estrogen's inhibitory signal to your pituitary gland and hypothalamus.
Current Prescribing Status
Enclomiphene is not currently FDA-approved as a standalone medication. Clomiphene (which contains both enclomiphene and zuclomiphene) is approved for female infertility, but off-label use in men for testosterone support is common in clinical practice.
Research into enclomiphene as a separate formulation is ongoing, with some studies suggesting it may offer advantages over clomiphene by providing only the active isomer without the longer-acting zuclomiphene component.
Who Might Consider It
Enclomiphene is sometimes prescribed off-label for men with low testosterone who want to preserve fertility or natural testosterone production. It's typically prescribed through telehealth and specialty clinics that focus on hormone health.