Letrozole for hormone receptor-positive breast cancer
Letrozole is an aromatase inhibitor that lowers estrogen levels to slow or stop breast cancer growth. Here's what you need to know about dosing, side effects and monitoring.
What letrozole does
Letrozole is an aromatase inhibitor, a class of drugs that lower estrogen levels in the body. It's used to treat hormone receptor-positive breast cancer in postmenopausal women by blocking the enzyme aromatase, which converts other hormones into estrogen.
How it's taken
Letrozole comes as a 2.5 mg tablet taken orally once daily. Treatment typically continues for 5 to 10 years, depending on your doctor's recommendation and your individual situation.
Common side effects
Most people tolerate letrozole well, but side effects can include:
- Hot flashes
- Joint pain and stiffness
- Fatigue
- Headache
- Nausea
- Bone thinning (osteoporosis with long-term use)
Side effects often improve over time. Report persistent or severe symptoms to your doctor.
Monitoring during treatment
Your doctor will schedule regular check-ups to monitor how well letrozole is working and watch for side effects. Bone density screening may be recommended, especially if you have risk factors for osteoporosis.
Cost and access
Letrozole is available as a generic medication, making it more affordable than many newer cancer drugs. Most insurance plans cover it for approved uses, though your copay or coinsurance will depend on your specific plan.
Questions to ask your doctor
- How long will I take letrozole?
- What side effects should I report immediately?
- Do I need bone density screening?
- Will letrozole interact with my other medications?