Testosterone undecanoate: what it is and how it works
Testosterone undecanoate is a long-acting form of testosterone replacement therapy. We explain dosing, side effects, costs and what to expect.
What is testosterone undecanoate?
Testosterone undecanoate is a synthetic form of testosterone, the primary male sex hormone. It's used to treat low testosterone (hypogonadism) in men whose bodies don't produce enough of it naturally.
Unlike shorter-acting testosterone formulations, undecanoate is a long-acting ester. This means it stays in your system longer between doses, typically requiring injections or oral doses less frequently than other testosterone replacement options.
How it works
Testosterone undecanoate works by replacing testosterone your body is missing or not producing in sufficient quantities. It binds to androgen receptors throughout your body to restore normal testosterone levels and the effects that come with them: increased muscle mass, bone density, energy levels and sexual function.
Forms and dosing
Testosterone undecanoate comes as:
- Injectable: typically 750 mg every 10 weeks (brand name: Aveed)
- Oral: available in some countries as capsules (brand name: Andriol)
Your doctor will determine the right dose based on your testosterone levels and symptoms.
Cost and insurance
Cost varies widely depending on your insurance coverage and whether you use the injectable or oral form. Injectable testosterone undecanoate is generally more expensive upfront than other testosterone formulations, though the longer interval between doses may offset this over time. Check your insurance formulary or ask your pharmacy for a specific price.
Side effects
Common side effects include acne, hair loss, mood changes and increased red blood cell count. Serious but rare side effects include blood clots and liver problems. Your doctor will monitor you with regular blood tests.
Getting testosterone undecanoate online
You can obtain testosterone undecanoate through telehealth providers who offer hormone replacement therapy. You'll need a consultation with a clinician, blood work to confirm low testosterone, and a valid prescription. Some telemedicine platforms specialise in testosterone replacement therapy and can manage ongoing monitoring.
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