Zepbound: Uses, Dosing, Side Effects and Cost
Zepbound (tirzepatide) is a once-weekly injection for weight management. See how it works, dosing schedules, common side effects, and what you might pay.
What is Zepbound?
Zepbound is the brand name for tirzepatide, a once-weekly injectable medication approved by the FDA for chronic weight management in adults. It works by mimicking two hormones that regulate appetite and blood sugar.
How it works
Zepbound activates receptors for GLP-1 and GIP, hormones that control hunger signals and glucose levels. This dual action reduces appetite and helps your body use energy more efficiently.
Dosing
Zepbound comes as a prefilled pen. Most people start at 0.25 mg once weekly, increasing gradually over 16 weeks to a maintenance dose of 2.4 mg weekly, depending on tolerance and response.
Common side effects
Nausea, vomiting, diarrhea, and constipation are typical, especially when starting or increasing doses. Most improve over time. Serious but rare side effects include pancreatitis and gallbladder issues.
Cost and insurance
Zepbound costs around $1,300 per month without insurance. Many insurers cover it for eligible patients, though prior authorization and documentation of medical need are usually required. GLP-1 coverage policies vary significantly by plan.
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